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Why Does Low-Dose Naltrexone Get Prescribed?

Low-dose naltrexone (LDN) has been shown to positively activate the immune system, and those suffering from cancer or other autoimmune disorders and diseases can greatly benefit from this.

As LDN is not an expensive drug, it does not have backing from a large drug company, and as such is not well-known. LDN differs from other drugs in its methodology; it does not treat the symptoms of a disease but rather aids in the regulation of bodily mechanisms that can create diseased states.

So why does low-dose naltrexone get prescribed? It gets prescribed because it shows potential in positively affecting the immune system, which enables the body to fight disease.

How Does LDN Help Fight Disease?

LDN is an opioid antagonist, which means that it blocks opioid receptors. This blocking of opioid receptors results in stimulating the immune system.

The latest research concerning the efficacy of LDN has shown that it does indeed target the opioid growth factor, known as OGF, and the opioid growth factor receptor, known as OGFr.

The LDN targets this pathway to impede cell proliferation. As cancer cells use the OGF/OGFr pathway to regulate their growth, LDN can regulate and inhibit the growth of these diseased cells by targeting the pathway mechanism.


LDN also impacts the immune system by interacting with the body’s endorphin levels. While endorphins are most widely thought of in terms of mood regulation, they also affect the regulation of pain, the immune system, and the growth rate of cells.

Endorphins also play a role in how blood vessels grow and feed a tumor: angiogenesis.

Taking LDN

Most often, prescribed LDN will be taken at night, prior to sleep. As the user sleeps, the LDN will block their opioid and endorphin receptors for a few hours throughout the night. The result of this is thought to be the up-regulation of powerful players within the immune system.

As the LDN stimulates an increase in the body’s manufacturing of its natural opioids, endorphins and metenkephalin, immune function is boosted and improved.

Diseases Affected by LDN

LDN has not only shown positive results in the fight against cancer, but also in numerous diseases and disorders where the immune system plays a crucial role. hepatitis C, lupus, colitis, Crohn’s disease, chronic fatigue syndrome, autism, HIV/AIDS, IBS, Parkinson’s disease, Alzheimer’s disease, multiple sclerosis, dermatomyositis, and diabetic neuropathies share a common feature: the primacy of the immune system coupled with low levels of endorphins in the blood results in immune deficiencies that cultivate diseased states.

Those suffering from cancer or autoimmune diseases and disorders may benefit from a low-dose naltrexone prescription. LDN’s efficacy in activating the body’s natural ability to fight off diseased states, and inhibit the growth of tumors through targeting the pathway used by cancer cells during growth carries great promise.

LDN is unique in its treatment methodology as it does not regulate or address the symptoms of diseases and disorders as many drugs do; instead, it aids in the regulation of bodily systems that can lead to diseased states. Thus, low-dose naltrexone has the unique and powerful ability to help the body heal itself by boosting the immune system.